Protein name:
    G1/S-specific cyclin-D3 ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.
    
 
    Function:
    Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Nucleus 
      
     
      Cytoplasm 
      
     
      Membrane 
      
    Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. 
  
    
 
    
    Protein Attributes:
    
    50:
    MELLCCEGTR |  HAPRAGPDPR |  LLGDQRVLQS |  LLRLEERYVP |  RASYFQCVQR |  
    
 
    100:
    EIKPHMRKML |  AYWMLEVCEE |  QRCEEEVFPL |  AMNYLDRYLS |  CVPTRKAQLQ |  
    
 
    150:
    LLGAVCMLLA |  SKLRETTPLT |  IEKLCIYTDH |  AVSPRQLRDW |  EVLVLGKLKW |  
    
 
    200:
    DLAAVIAHDF |  LAFILHRLSL |  PRDRQALVKK |  HAQTFLALCA |  TDYTFAMYPP |  
    
 
    250:
    SMIATGSIGA |  AVQGLGACSM |  SGDELTELLA |  GITGTEVDCL |  RACQEQIEAA |  
    
 
    292:
    LRESLREASQ |  TSSSPAPKAP |  RGSSSQGPSQ |  TSTPTDVTAI |  HL
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
        Bovine
         
        
        Rat
         
        
     
    
        ELISA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D3
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-259 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-259 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ALA-259 
                    
                    
                    tissue :
                    
Cervix carcinoma .  
             
         
            
        
            
                5.
                
                    
                        
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                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4);VARIANT ALA-259 
                    
                    
                    tissue :
                    
Synovium . tissue :
                    
Thymus . tissue :
                    
Umbilical cord blood .  
             
         
            
        
            
                6.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-259 
                    
                    
                 
             
         
            
        
            
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                            Tubby B. 
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                            Nature425:805-811(2003)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                8.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
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Hannenhalli S. 
                        ,
                            
Turner R. 
                        ,
                        
                        
                            Yooseph S. 
                        ,
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                              more...   
                             
                        
                        
                            Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-259 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Lung .  
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-237 
                    
                    
                    tissue :
                    
Placenta .  
             
         
            
        
            
                11.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH CDK4 AND CDKN1A 
                    
                    
                 
             
         
            
        
            
                12.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH ATF5;FUNCTION;SUBCELLULAR LOCATION 
                    
                    
                 
             
         
            
        
            
                13.
                
                    
                    
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                        Cited for INTERACTION WITH EIF3K 
                    
                    
                 
             
         
            
        
            
                14.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH CDK4; CDKN2A AND CDKN1B 
                    
                    
                 
             
         
            
        
            
                15.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Cervix carcinoma .  
             
         
            
        
            
                16.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Leukemic T-cell .  
             
         
            
        
            
                17.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for UBIQUITINATION BY SCF(FBXL2) 
                    
                    
                 
             
         
            
        
            
                18.
                
                    
                        
                            "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." 
                        
                        
                            Van Damme P. 
                        ,
                            
Lasa M. 
                        ,
                            
Polevoda B. 
                        ,
                            
Gazquez C. 
                        ,
                            
Elosegui-Artola A. 
                        ,
                            
Kim D.S. 
                        ,
                            
De Juan-Pardo E. 
                        ,
                            
Demeyer K. 
                        ,
                            
Hole K. 
                        ,
                            
Larrea E. 
                        ,
                            
Timmerman E. 
                        ,
                            
Prieto J. 
                        ,
                            
Arnesen T. 
                        ,
                            
Sherman F. 
                        ,
                            
Gevaert K. 
                        ,
                            
Aldabe R. 
                        
                        
                        
                        
                            Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                 
             
         
            
        
            
                19.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH CDK4